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DANOCRINE (DANAZOL) CAPSULES: PRECAUTIONS

Because Danocrine (Danazol) capsules may cause some degree of fluid retention, conditions that might be influenced by this factor, such as epilepsy, migraine, or cardiac or renal dysfunction, polycythemia and hypertension require careful observation. Use with caution in patients with diabetes mellitus.

Since hepatic dysfunction manifested by modest increases in serum transaminases levels has been reported in patients treated with Danocrine, periodic liver function tests should be performed.

Administration of Danazol has been reported to cause exacerbation of the manifestations of acute intermittent porphyria.

Laboratory monitoring of the hematologic state should be considered.

Laboratory Tests

Danazol treatment may interfere with laboratory determinations of testosterone, androstenedione and dehydroepiandrosterone. Other metabolic events include a reduction in thyroid binding globulin and T4 with increased uptake of T3, but without disturbance of thyroid stimulating hormone or of free thyroxin index.

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